Novel Synthesis and Characterization of Thiosemicarbazone Compounds Containing 4-Acyl-2-pyrazolin-5-ones

Novel Synthesis and Characterization of Thiosemicarbazone Compounds Containing 4-Acyl-2-pyrazolin-5-ones

Abstract:  

A novel synthesis of 4-acylthiosemicarbazone-3-methyl-1-(4`-methylphenyl)-2-pyrazolin-5-one by condensation  of  4-acyl-3-methyl-1-(4`-methylphenyl)-2-pyrazolin-5-one  with  thiosemicarbazide  is  carried  out.  The compounds were characterized on the basis of elemental analysis, IR, 1H NMR, Mass, DSC  and 

13C NMR  spectral  data.  The  structures were  investigated  for  their  antibacterial  and  antifungal  activity.  They  are  very  essential  to  study  on cerebral infarction (Free radical scavenger). A single crystal X-ray study of this thiosemicarbazones and their metal complexes is in progress. 

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